Parkinson's disease, pesticides, and glutathione transferase polymorphisms. | Toxins and Parkinsons | Detox the brain with glutathione for parkinsons

See below article on how low glutathione levels can make on susceptible to injury to the brain which could become Parkinsons from pesticide exposure. Keep in mind that Glutathione is poorly absorbed through the GI tract when taken orally. The reason for the suppository for is that it’s absorbed there and you have a slow release of Glutathione through the colon that peaks for about 5-6 hours. Thats an amazing time frame that your body has to absorb the Glutathione into the brain and into the cells of your body. GlutaGenic also keeps it’s high potency products cold through storage and shipping which ensures the most potent product on the market. Try a month and see the difference. 

The Lancet

Volume 352, Issue 9137, 24 October 1998, Pages 1344–1346

Summary

Background

Parkinson’s disease is thought to be secondary to the presence of neurotoxins, and pesticides have been implicated as possible causative agents. Glutathione transferases (GST) metabolise xenobiotics, including pesticides. Therefore, we investigated the role of GST polymorphisms in the pathogenesis of idiopathic Parkinson’s disease.

Methods

We genotyped by PCR polymorphisms in four GST classes (GSTM1, GSTT1, GSTP1, and GSTZ1) in 95 Parkinson’s disease patients and 95 controls. We asked all patients for information about pesticide exposure.

Findings

The distribution of the GSTP1 genotypes differed significantly between patients and controls who had been exposed to pesticides (controls vs patients: AA 14 [54%] of 26 vs seven [18%] of 39; AB 11 [42%] of 26 vs 22 [56%] of 39; BB 1 [4%] of 26 vs six [15%] of 39; AC 0 vs four [10%] of 39, p=0.009). No association was found with any of the other GST polymorphisms. Pesticide exposure and a positive family history were risk factors for Parkinson’s disease.

Interpretation

GSTP1-1, which is expressed in the blood-brain barrier, may influence response to neurotoxins and explain the susceptibility of some people to the parkinsonism-inducing effects of pesticides.

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by GlutaMaster