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Reduced and oxidized glutathione concentrations in post-mortem brain tissue from the substantia nigra of control subjects and patients with neuropathologically confirmed Parkinson’s disease were measured by a coulometric method using high-pressure liquid chromatography and electrochemical detection. Reduced glutathione concentrations were decreased in the substantia nigra of parkinsonian patients compared with controls. Differences in the concentration of oxidized glutathione and in the percentage of oxidized glutathione of the total glutathione were not observed between parkinsonian and control subjects. The finding that oxidized glutathione is not decreased in Parkinson’s disease suggests that the decrease in reduced glutathione is not exclusively the consequence of neuronal loss in the substantia nigra but may indicate a state of oxidative stress.
Keep in mind that Glutathione is poorly absorbed through the GI tract when taken orally. The reason for the suppository for is that it’s absorbed there and you have a slow release of Glutathione through the colon that peaks for about 5-6 hours. Thats an amazing time frame that your body has to absorb the Glutathione into the brain and into the cells of your body. GlutaGenic also keeps it’s high potency products cold through storage and shipping which ensures the most potent product on the market. Try a month and see the difference.