SandMan™ (Glutathione & Melatonin suppository)

$150.00 $120.00

SandMan™ contains 250mg of glutathione, 200mg of Melatonin, Proprietary blend of SandMan Complex™ (CBD from whole plant hemp extract and theanine), terpenes along with our proprietary AP0-808™ probiotic strain, the body’s most powerful anti-oxidant (Glutathione) is combined with the brains primary anti-oxidant (melatonin) along with SandMan Complex™ for neurotransmitter support for Gaba to aid in deep relaxation.

  • Video Testimonial
  • Melatonin Is Simply Amazing!
  • Active Ingredients
  • Dosage and Storage Instructions
  • How Is ABC Different?
  • This Product is Effective Against
  • Supplement Facts
  • A Statement From The FDA
  • Description

Melatonin is simply amazing!

  • It’s the Most powerful antioxidantavailable in our body.
  • Melatonin is the strongest free radical scavenger in our body above even Vitamin C and E.*
  • Mitochondrial dysfunction is one of the main causative complications of many diseases, especially the neurodegenerative diseases. Studies have shown Melatonin has a powerful, positive effect on mitochondria function.*
  • Very high amounts are best for melatonin to exert its antioxidant effect. This is called a Supraphysiologic dosage. (100-400mg)*
  • Melatonin has been studies on animals for any negative effects in very high doses which would be similar to up to 10,000mg on an average human with zero toxicity.*
  • May support prevention of and treatments for Parkinson’s Alzeihmers, Leaky Gut, Cancer, Heart Disease, Aging, Diabetes, Autism, and Chronic Inflammatory Diseases such as with Fibromyalgia, Chronic Lyme, CIRS (Mold Illness).*
  • Melatonin has been shown in hundreds of studies to inhibit cancer growth.*
  • Studies show no negative feedback loop on hormones with regular use of Melatonin.*


Glutathione: Besides all of its antioxidant benefits,  oxidized glutathione (GSSG) is an active component of sleep-promoting substance (SPS). The administration Glutathione in its reduced form induced the maximal increase in the total time of nocturnal sleep (35-86% above the baseline) in experimental animal studies. The sleep-enhancing activity of GSSG was caused by its physiological modulation of stress neurotransmission in the brain from the glutamate modulation.

L-theanine may help people fall asleep more quickly and easily at bedtime, thanks to the relaxation boost it delivers. Research also shows L-theanine can improve the quality of sleep—not by acting as a sedative, but by lowering anxiety and promoting relaxation through its action on the neurotransmitter GABA.

Terpenes: These are the NON phycoactive components in cannabis. They are the fragrant essence of ALL essential oils! They give plants their unique smell and they also hold the healing benefits within the plants. Terpenes have been studied exensivly and they are at the forefront of interest of the pharmacuetical companies due to the unique and safe profile they can have. Terpenes that are specifically shown to improve sleep with a sedative effect, reduce pain, are anti inflammatory and reduce anxiety have been incorperated into Sandman.* These terpenes also have been shown to improve CBD and other cannabinoids utilization and uptake into the brain.*

Myrcene (or β-myrcene) is a terpene that occurs often in highly fragrant plants and herbs such as mangoes, hops, bay laurel leaves, thyme, lemongrass, and basil. Myrcene is produced by numerous cannabis strains, and some rodent-model studies have suggested that it might lend sedative effects. Main effects are Sleep Promoting, Anti-inflammatory, Analgesic (pain relief), Antibiotic, Sedative and Antimutagenic (anti cancer).*

Another place you’ll find myrcene is in mangoes. Anecdotal evidence suggests that eating a ripe mango prior to consuming cannabis may accentuate or extend the effects of cannabinoids; some have suggested that this is due to the fruit’s concentrations of myrcene, which is naturally synergistic with CBD and allows cannabinoids to more easily bridge the blood-brain barrier.

Linalool is a naturally occurring terpene found in many flowers and spices including lavender and coriander. It gives off a complex yet delicate floral aroma, and while its effects are myriad, it is in particular one of the substances used most widely to reduce stress. Humans have inhaled the scent of certain plants, including many containing linalool, since ancient times to help lower stress levels, fight inflammation, and combat depression.* Linalool has been the subject of many studies, including a recent one in which scientists allowed lab rats to inhale linalool while exposing them to stressful conditions. It was reported that linalool returned elevated stress levels in the immune system to near-normal conditions. Linalool’s Effects and Benefits include Sleep Promoting, anti-anxiety, Antidepressant, Sedative, Anti-inflammatory, Anti-epileptic and Analgesic.*


Dosage and Storage Instructions

Wash your hands thoroughly with soap and water. Keep the suppository in the refrigerator so it remains hard before removing the wrapper. Put on a finger cot or disposable glove, if desired (available at a pharmacy). Lubricate the suppository with a water soluble lubricant such as K-Y Jelly or coconut oil, not petroleum jelly (Vaseline). If you do not have this lubricant, moisten your rectal area with cool tap water. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach. Lift upper buttock to expose the rectal area. Insert the suppository, pointed end first, with your finger until it passes the muscular sphincter of the rectum, about ½ to 1 inch in infants and 1 inch in adults (If not inserted past this sphincter, the suppository may pop out). Hold buttocks together for a few seconds. Remain lying down for about 5 minutes to avoid having the suppository come out. Discard used materials and wash your hands thoroughly.

Suggested dosage is 1 (one) suppository daily. Depending on your daily schedule, it is recommended that you insert the suppository prior to bed.


Product is not intended for oral usage although it can be consumed orally.

Store this product in a refrigerated climate. Keep this product away from sunlight. Please use the product within six months of purchase date for best results.

Sustained-release technology is ABC’s suppositories are of benefit due to increased bioavailability. ABC has found that the addition of SRT™ improved the bioavailability of glutathione by 30% compared to the suppositories without SRT™. These absorptions were improved enormously by the addition of a proprietary and natural polypeptide. Eexcellent prolonged absorption and high bioavailability were obtained exhibiting both high plasma level and prolonged absorption. Our research shows that ABC’s preparations containing SRT™ may be superior in a rectal preparation with prolonged action and giving a high plasma level compared to standard suppository bases without ABC’s SRT™!

Why do we use probiotics in our suppositories?

APO-808™ is a proprietary blend of probiotic strains that is unique to our suppository technology. ABC has discovered certain bacteria strain combination of probiotics can support the absorption and utilization when combined with various ingredients. Probiotics are beneficial bacteria that exist in our large intestine as what is called the microbiome, which is exactly where the suppository is absorbed. Using probiotics via suppository makes for a unique route of delivery as it bypasses the acid in the stomach that normally destroys most probiotics taken orally. In addition it has been clinically shown that oral probiotics may not even colonize your gut at all. Due to the need for the probiotics to be incorperated into the gut wall, research has shown we might be wasting our money taking most probiotics orally.  ABC’s probiotic strains have been combined with our special suppository base, which consists of organic palm oil. This combiunation rests on the gut wall over a 5-8 hour period to allow for the incorperation and colonization of the bacteria in the large intestines. Besides the unique delivery of the probiotics via suppository route it has been scientifically shown that many nutrients are brought into the blood stream by various strains of beneficial flora in your microbiome. The scientists at ABC have isolated various combination of flora that work specifically with the nutrients it is combined with.

APO-808™ is designed to work with Glutathione in particular to down regulate the inflammation through normalizing the gut microbiome as well as alowing maximum absorption of Glutathione. 

The strains contained in the APO-808™ Blend have been shown in the research to help with the following:

  • Diarrhea. Including viral diarrhea in children, traveler’s diarrhea, and diarrhea caused by antibiotics.
  • Growth of bacteria in the intestine.
  • Helicobacter pylori infection. Which causes ulcers.
  • Inflammatory bowel disease(IBD, Crohn’s disease, ulcerative colitis).
  • Cancer prevention.
  • Clostridium difficile colitis.
  • Digestion problems.
  • Immune system strengthening. (Helpful in Chronic Lyme, CIRS, and EBV)
  • Irritable bowel syndrome (IBS).


Supplement Facts

Serving size: 1                                              Servings: 15

Amount Per Piece                                       % Daily Value

L Glutathione                                                   250mg

Melatonin                                                         200mg

Theanine, Hemp/CBD Extract.                    *****

Terpenes: Myrcene, Linalool                        *****

AP0-808™ Probiotic Blend                           *****

SRT™ Polysaccharide Complex.                   *****

Daily Value not established

Advanced Biome Corp™ does not sell or distribute any products that are in violation of the United States Controlled Substances Act (USA CDA). The company does sell and distribute hemp-based products.


  • Although safe for children, this product should be kept out of the reach of children.
  • Do not use if the suppositories are open or damaged.
  • As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

Most or our customers have chosen to administer this product rectally as a suppository or as a vaginal pessary.  Please know that this product can be taken safely by mouth as well. When taken orally it is a dietary supplement in accordance with current FDA guidelines.


The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent disease or medical conditions. The products and information found on are not intended to replace professional medical advice or treatment. Individual results may vary. Advanced Biome Corp urges you to seek the advice of a qualified professional for any health concern, and to share with your provider any information pertaining to your health and well-being, including the use of supplemental nutrition. We try our best not to make mistakes; however, if typographical errors appear in our site, we cannot be held responsible. All information presented here is not meant as a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions or other complications before using any product. The Federal Food, Drug, and Cosmetic Act require this notice.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, with oral use it is a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff).

ABC’s product line is a naturally derived FDA GRAS (Generally regarded As Safe) mineral, herbal, vitamins and nutraceutical products  which can be legally sold in the USA. ABC’s products are not a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). ABC’s products are not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice.

This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor’s advice should be sought before using this and any supplement dietary product. All trademarks and copyrights are the property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.

All Products Sold Have Less Than 0.3% THC



Sleep Quality is the Holy Grail for a Happy & Healthy Life!

SandMan™ contains 250mg of glutathione, 200mg of Melatonin, (Non THC containing) Cannabis Terpenes, Proprietary blend of SandMan Complex™ (CBD from whole plant hemp extract and theanine) along with our proprietary AP0-808™ probiotic strain, the body’s most powerful anti-oxidant (Glutathione) is combined with the brains primary anti-oxidant (melatonin) along with SandMan Complex™ for neurotransmitter support for Gaba to aid in deep relaxation.  This is the most advanced and strongest Sleep support with a slow release over a 5-7 hour period to support sleep all night long due to our proprietary slow release technology using SRT ™ Polysaccharide Complex. Deep sleep has been shown clinically to support the break down of amyloid beta protein tangles. Diseases such as Alzeihmers have been linked to poor deep sleep where these protein tangles can accumulate and destroy normal function of the brain. Another important and recent finding in science of sleep is that Deep sleep cleanses the brain. The waste removal system of the brain, the glymphatic system, is at its most efficient during deep sleep, a recent international study shows it may be possible that getting too little deep sleep prevents glymphatic clearance and causes neurological diseases. Basically your neurons will be swimming in their own excrement without adequate deep sleep. Deeper sleep has been shown to improve all neurodegenerative diseases, diabetes, arthritis, immune function and more. Diseases that deep sleep might support in particular include Parkinson’s disease, Alzeihmers, Fibromyalgia, Chronic Fatigue, Lyme disease, CIRS, Mold Illness, MS, and many Autoimmune conditions.*